Neonatal Hypertrophic Cardiomyopathy In An Infant With Osteogenesis Imperfecta Type I

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We report an association between neonatal hypertrophic cardiomyopathy and osteogenesis imperfecta type I. A preterm infant with cardiorespiratory distress was noted to have severe hypertrophic cardiomyopathy in the early neonatal period. She was treated with b-blockers and had gradual complete resolution of abnormal left ventricular and septal echocardiographic indices over the next four weeks. She had no clinical features directly attributable to her cardiomyopathy during this time. Subsequently, evidence of bone fragility led to a diagnosis of osteogenesis imperfecta type I being established.