Near-term and long-term efficacy of radiofrequency ablation for primary hepatocellular carcinoma and correlation analysis of serum miR-202 levels

Abstract

Objective To investigate the short-term and long-term efficacy of radiofrequency ablation in the treatment of early primary liver cancer and the correlation of serum miR-202 levels. Methods Retrospective analysis of 68 patients with early primary liver cancer from January 2010 to December 2013, patients were treated with radiofrequency ablation in our hospital. SPSS21.0 statistics software was used for data analysis. The serum miR-202 level and other measurement data were expressed as (±s) and compared with the independent t test. P<0.05 was statistically significant. Results After radiofrequency ablation, 33 patients with CR, 27 patients with PR, 6 patients with SD, and 2.9 patients with PD, the total effective rate was 88.2%. The 1-year survival rate was 57 (83.8%), the 3-year survival rate was 33 (48.5%), the 5-year survival rate was 20 (29.4%), and the recurrence rate was 35(51.5%). The serum miR-202 level of patients before treatment was(0.5±0.2) and after treatment was(1.0±0.2). After treatment was significantly higher than that before treatment (t=13.734, P=0.000). The short-term efficacy was better in patients with high expression of micro RNA-202 after treatment (40 cases) (P<0.05), the 5-year survival rate was higher (P<0.05), and the number of patients with recurrence after operation was fewer (P<0.05). Conclusion Serum miR-202 levels and radiofrequency ablation for the treatment of early primary liver cancer in the near-term and long-term efficacy are relevant, the higher the level of serum miR-202 after treatment, the better the efficacy in the near-term and long-term. Key words: Carcinoma, hepatocellular; Ablation techniques; Treatment outcome; MicroRNAs