Abstract
By the modification of solid-lipid nanoparticles (SLNs), the nano-structured lipid carriers (NLCs) were obtained by the modification of nanostructured that hold the qualities of the SLN, increases the stability of the drug, and prevents drug leakage. The limitations of the drugs that are delivered in the body using different routes are poor solvency, first pass metabolism, and poor bioavailability hence to overcome these limitations NLCs were prepared. Oral, topical, transdermal, ocular, and parenteral are the different routes through which nanobased systems are delivered. Spatially incompatible liquid lipids and solid lipids are blended and NLCs were prepared. It stays solid at room temperature. The advantages of for drug therapy over conventional carriers NLCs are increased solubility, improved bioavailability. This review describes about the NLC, its advantages and disadvantages, types, NLC techniques, mode of action, and applications of NLC. Imperfect, amorphous, and multiple types are the main three types of NLCs. Lipids, liquid lipids, solid lipids, Emulsifiers, ultraviolet (UV) blockers, and aqueous medium were the excipients used. Microemulsion technique, microemulsion based SLN/NLC preparations, solvent diffusion method, high-pressure homogenization (HPH), hot and cold homogenization techniques, and melt emulsification method are the techniques used for the preparation of NLC. The applications of NLCs are for ocular, brain targeting, topical, cancer therapy, cosmetics, and analgesia.
Highlights
Nanostructures are the particles which range from 10 to 1000 nm, by which the drug molecules are absorbed or attached which are dissolved, entrapped
nano-structured lipid carriers (NLCs) are the second generation of lipid nanocarriers and are made up of matrix which contains solid lipid and liquid lipid
The types and concentrations of lipids and emulsifiers used to manufacture NLCs have to influence on loading capacity, entrapment efficiency, discharge characteristics, and physicochemical stability
Summary
Nanostructures are the particles which range from 10 to 1000 nm, by which the drug molecules are absorbed or attached which are dissolved, entrapped. NLCs are the second generation of lipid nanocarriers and are made up of matrix which contains solid lipid and liquid lipid. To overcome the disadvantages of SLN, NLCs have been developed. Combination of solid and liquid lipids and SLNs were modified as the delivery systems synthesized by cooling and heating crystallization. The carriers used for the NLCs are biodegradable and exhibits low in vivo toxicity. Solid and liquid lipids are mixed and are used for the preparation of aqueous dispersions of solid nanoparticles, and stabilized by one or two surfactants. Usage of physiological lipids is the major advantage of SLNs. Low incorporation due to the crystalline structure of solid lipids is the major disadvantage of SLNs as drug carriers. Biodegradability, greater drug protection is the advantages which were exhibited by the NLCs
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call