Nanostructured Lipid Carriers: A Vital Drug Carrier for Migraine Treatment

Abstract

Migraine is a very mysterious and much-misunderstood disorder characterized by pulsating headache in one side of the head in the form of attacks lasting from 4-48 hrs. It is a complex neurological condition, in this condition which can affect the whole body with many symptoms. However to cure this and effective treatment the nanostructured lipid carriers are used as widely nowadays. This use of structures ranges from the size 1-100nm with the main aim to develop the medicine to diagnose as accurately and effectively with less or no side effects. As we developed the stability and leakage of drugs is also improved. As we know the limitations from the different routes of administration are first-pass metabolism, poor bioavailability, and poor solvency to overcome these limitations Nanostructured lipid carriers (NLCs) were prepared. Transdermals, ocular, oral, topical, and parenteral are the different routes through which Nano based systems are delivered. Spatially incompatible liquid lipids and solid lipids are blended and NLCs were prepared. The main advantages of drug therapy over conventional carriers NLCs are improved bioavailability, increased solubility. This review describes the NLC used for the migraine treatments, its advantages, and disadvantages, types, NLC techniques, mode of action, of NLC. Imperfect, amorphous, and multiple types are the main three types of NLCs. Lipids like solid and liquid, Emulsifiers, and aqueous medium were the excipients used. Micro-emulsion technique, micro-emulsion-based SLN/NLC preparations, solvent diffusion method, high-pressure homogenization (HPH), hot and cold homogenization techniques, and melt emulsification method are the techniques used for the preparation of NLC.