Abstract
Abstract Electro-oxidation and determination of an antihistamine drug was carried out to study its electrochemical behavior by constructing a new sensor using silica nanoparticles. The response towards cetirizine oxidation process was excellent with good conductivity in the transfer of the electrons involved in the oxidation process. The homogeneous mixture of silica nanoparticles and graphite powder exhibits good response time, stability, sensitivity and reproducibility. A significant increase in the oxidation peak current was observed in phosphate buffer solution (PBS). Effect of accumulation time, scan rate, pH, concentration, excipients, and metal ions on the voltammetric behavior of the drug was studied by various voltammetric techniques. The catalytic properties of nanosilica particles reveal an increase in the peak current with less negative value of the potential. The relationship between scan rate and peak potential direct to calculate number of electrons and protons involved in the electro-oxidation process. A linear plot was obtained by varying the concentrations of the cetirizine. A low detection limit value and good recovery values shows us an applicability of the proposed electrode for tablet and urine samples analysis.
Published Version
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