Abstract
Abstract An anti-viral drug, acyclovir (ACV) nanolevel detection and determination has been carried out using zinc oxide (ZnO) nanoparticles modified glassy carbon electrode. The construction of sensor involves fabrication of the working electrode with nanoparticles suspension. Due to increase in the surface area the peak current enhanced greatly. The ZnO nanoparticles showed good conductivity, stability, sensitivity towards electro-oxidation of ACV in all the pH range studied 3.0 -11.2 phosphate buffer solutions (PBS). The relationship between scan rate and peak potential with correlation coefficient was used to calculate number of electrons and protons involved in the electro-oxidation process. A linear plot was obtained by varying the concentrations of ACV. A probable reaction mechanism was also proposed. The limit of detection, quantification, heterogeneous rate constant values was calculated. A low detection limit value and good recovery values shows us an applicability of the proposed electrode for tablet and urine samples analysis.
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