Abstract
Nanoparticles (NPs) are very promising for the intracellular delivery of anticancer andimmunomodulatory drugs, stem cell differentiation biomolecules and cell activitymodulators. Although initial studies in the area of intracellular drug delivery have beenperformed in the delivery of DNA, there is an increasing interest in the use of othermolecules to modulate cell activity. Herein, we review the latest advances in theintracellular-targeted delivery of short interference RNA, proteins and small moleculesusing NPs. In most cases, the drugs act at different cellular organelles and therefore thedrug-containing NPs should be directed to precise locations within the cell. This will leadto the desired magnitude and duration of the drug effects. The spatial control in theintracellular delivery might open new avenues to modulate cell activity while avoidingside-effects.
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