Naloxone in treatment of elderly chronic obstructive pulmonary disease complicated with pulmonary encephalopathy

Abstract

Objective To investigate the clinical efficacy of naloxone in treatment of elderly chronic obstructive pulmonary disease complicated with pulmonary encephalopathy.Methods Seventy elderly cases of chronic obstructive pulmonary disease complicated with pulmonary encephalopathy were selected from October 2009 to October 2011,and were randomly divided into observation group and control group and 35 cases in each group.The routine therapy was used to both groups,Naloxone was given to observation group.Breathing,heart rate,arterial blood gas analysis before treatment and 48 hours after treatment in two groups were observed.Results The heart rate,blood pressure,arterial partial pressure of oxygen,arterial partial pressure of carbon dioxide in observation group after treatment for 48 hours compared with those in control group after treatment for 48 hours,the difference was statistically significant (P ＜0.05) ;The total efficiency in observation group after treatment was 94.2％.The total efficiency in control group after treatment was 74.2％.The total effective rate in observation group were significantly higher than that in control group,the difference was statistically significant (P ＜0.05).Conclusions Naloxone in the treatment of elderly chronic obstructive pulmonary disease complicated with pulmonary encephalopathy has significant clinical effect,and the therapy is worthy of reference. Key words: Chronic obstructive pulmonary disease; Pulmonary encephalopathy with naloxone ; Elderly ; Naloxone