Abstract
AbstractA palladium‐catalyzed allylic alkylation of unsubstituted 2‐cyanoacetates using a 1,1′‐bi‐2‐naphthol‐derived multifunctional N,O,P ligand is reported. A number of chiral monosubstituted 2‐cyanoacetates with two adjacent stereogenic carbon centers are obtained in this Pd‐catalyzed asymmetric allylic alkylation reaction, in which the multistereogenic and multifunctional 1,1′‐bi‐2‐naphthol‐derived N,O,P ligand‐promoted Pd‐catalyzed asymmetric allylic alkylation reaction proceeds smoothly in high diastereo‐ and enantioselectivity (up to >99:1 dr and up to 96 % ee).
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