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Abstract
Simple SummaryEstrogenic endocrine disruptive chemicals (E-EDCs) are important types of pollutants in fish farms worldwide and a globally concerned problem. In this study, Nile tilapia fish farms receiving wastewater effluents in Egypt were selected as highly, moderately polluted fish farms; besides, a putative control site was deemed low in contamination. Levels of E-EDCs (natural and synthetic steroids, and industrial phenolic compound/bisphenol A (BPA)) was recorded in farm water, and fish tissues at all sites under consideration, mainly, lower levels of testosterone, progesterone, zeranol, and 17β-estradiol were detected compared to the higher level of BPA. Moreover, the effects of these pollutants on fish biometric, reproductive genes, and hormonal biomarkers was evaluated along with the observed associated histopathological alterations. Our findings revealed the detection of some steroidal compounds with a higher level of the BPA. All analyzed biomarkers were reduced to a great extent in the highly polluted sites compared to others, and the histopathological alterations observed were supportive of other measurements. These observations warrant strict monitoring of aquatic pollution sources and the development of strategic plans to control aquaculture pollution.This study was undertaken to screen levels of xenosteroids (estrogenic endocrine disrupting chemicals/E-EDCs) in Nile tilapia (Oreochromis niloticus) fish farms subjected to water fill from the drain at three sites S1 (highly polluted), S2 (moderately polluted), and a putative reference site (RS). Biometric, hormonal, gene expression, and histopathological analysis were investigated. Testosterone, progesterone, and zeranol residues were detected at (0.12–3.44 µg/L) in water samples of different sites. Bisphenol-A (BPA) exhibited a very high concentration (6.5 µg/mL) in water samples from S1. Testosterone, 17β-estradiol residues were detected in fish tissues from all sites at (0.16–3.8 µg/Kg) and (1.05–5.01 µg/Kg), respectively. BPA residues were detected at a very high concentration in the liver and muscle of fish collected from S1 at higher levels of 25.9 and 48.07 µg/Kg, respectively. The detected E-EDCs, at different sites, particularly BPA, reduced the somatic and testicular growth among sites and oversampling time points. Meanwhile, hepatosomatic index (HSI) was significantly increased in S1 compared to S2. All analyzed genes estrogen receptor-type I (er-I, er-ɑ) and II (er-II, er-ß1), polypeptide 1a (cyp19a1), SRY-box containing gene 9 (sox9), and vitellogenin (vtg) and gonadotropin hormones (luteinizing hormone (LH), follicle-stimulating hormone (FSH)), testosterone, 17β-estradiol, and anti-Mullerian hormone (AMH) were significantly expressed at S1 compared to other sites. Histopathology was more evident in S1 than other sites. These findings warrant immediate strategies development to control aquatic pollution and maintain fish welfare and aquaculture sustainability.
Highlights
The aquaculture industry in Egypt is a fast-growing sector contributing about 77% of the total national fish production [1,2,3]
Bioaccumulation of testosterone, 17β-estradiol, and BPA were detected in fish tissues
In the present study, we observed a significant increase of sox9 mRNA expression level in testes in Site 1 (S1) where Endocrine Disrupting Chemicals (E-EDCs) contamination was higher than at the other sites and where the fish would be expected to be feminized by the estrogenic hormones
Summary
The aquaculture industry in Egypt is a fast-growing sector contributing about 77% of the total national fish production [1,2,3]. Reproductive performance is the crucial feature in interpreting the population dynamics of fish that have implications for fish sustainability [4]. The increased demand for fish production as a vital source of animal protein, mainly in urban and rural areas, has led to over expansion of aquaculture [7,8,9]. Serious constraints are emerging as a result of aquaculture expansion. To reserve high-quality water for human and agricultural use, Egyptian legislation only allows aquaculture facilities to make use of water from drains, including water that had been released from wastewater plants or had been used for agricultural purposes
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