Abstract
Epigenetic refers to DNA methylation, histone modification and histone variants, to change expression level of heritable molecular determinants without the changing DNA sequence. With the development of the sequencing and protein identification technology, a large number of studies from International Cancer Genome Consortium(ICGC) illustrates Epigenetic alterations play an important part in cancer initiation and metastasis. The proteomic and genomic studies find out the potential connection and mechanism between epigenetics and cancers. Nowadays, the epigenetic inhibitors are still the main therapies in clinical treatments. This article aims to find out the relationship between DNA methylation and cancer, and create a new version, where epigenetic alterations combines cancer cells to open a new gate of organ transplantation. In conclusion, using DNA methylation to transform the cancer cells into specific cells to build a new organ may solve the most common problem, cell pairings, in organ transplantation.
Published Version
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