Abstract
Putranjiva roxburghii Wall is traditionally used by tribals for treating various health problems. In this study, Analgesic, anti-inflammatory and anti-oxidant activities of ethanolic extract of leaves and stem of Putranjiva roxburghii were evaluated in rats using different evaluatory models for each activity. Carrageenan-induced paw edema, croton oilinduced ear edema and anus edema models were used for evaluating anti-inflammatory activity. Analgesic activity was evaluated by acetic acid induced writhing model, Eddy’s hot plate model and tail flick models. The plant extract was also evaluated for its In-vitro anti oxidant activity in an attempt to find its potency in providing protection against free radical induced diseases. The results indicates significant dose dependant anti inflammatory activity of ethanolic extract (250 and 500 mg/kg, p.o.) of Putranjiva roxburghii wall with respect to standard drug Indomethacin. The extract showed dose dependent analgesic activity in acetic acid induced writhing model but dose independent activity in case of hot plate and tail flick models as compared to standard drug Indomethacin. The In-vitro antioxidant activity of the ethanolic extract was also significant and comparable with ascorbic acid in both DPPH and H2O2 models.
Highlights
In the modern era, synthetic drugs have gradually replaced the natural drugs due to their cost-effectiveness, abundant availability and prompt therapeutic response
The level of interest in the research of natural products has increased over the last few years, with particular emphasis being placed on the investigation of bioactive compounds of plant origin[3].This has led to the discovery of potentially useful molecules considered worthy for clinical application[4]
Putranjiva roxburghii Wall commonly called in Telugu by names Kuduru, Putrajivika and in Hindi as Putijia belongs to the family Euphorbiaceae grows abundantly in forests of khammam districtict of Andhra Pradesh
Summary
Synthetic drugs have gradually replaced the natural drugs due to their cost-effectiveness, abundant availability and prompt therapeutic response. India is having a very rich resource of forests inhabited by different tribal groups. Many of these forests are not reachable for extending the modern system of medicine to the tribals and they depend mainly on these forests wealth for the treatment of many diseases[5]. Putranjiva roxburghii Wall commonly called in Telugu by names Kuduru, Putrajivika and in Hindi as Putijia belongs to the family Euphorbiaceae grows abundantly in forests of khammam districtict of Andhra Pradesh. It is widely grown in Thailand, Nepal, Bangladesh, India, Myanmar and Sri Lanka[7]
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