Abstract
The PRHD@MnFe2O4 binary hybrids have shown a potential for applications in the biomedical field. The polymer cover/shell provides sufficient surface protection of magnetic nanoparticles against adverse effects on the biological systems, e.g., it protects against Fenton’s reactions and the generation of highly toxic radicals. The heating ability of the PRHD@MnFe2O4 was measured as a laser optical density (LOD) dependence either for powders as well as nanohybrid dispersions. Dry hybrids exposed to the action of NIR radiation (808 nm) can effectively convert energy into heat that led to the enormous temperature increase ΔT 170 °C (>190 °C). High concentrated colloidal suspensions (5 mg/mL) can generate ΔT of 42 °C (65 °C). Further optimization of the nanohybrids amount and laser parameters provides the possibility of temperature control within a biologically relevant range. Biological interactions of PRHD@MnFe2O4 hybrids were tested using three specific cell lines: macrophages (RAW 264.7), osteosarcoma cells line (UMR-106), and stromal progenitor cells of adipose tissue (ASCs). It was shown that the cell response was strongly dependent on hybrid concentration. Antimicrobial activity of the proposed composites against Escherichia coli and Staphylococcus aureus was confirmed, showing potential in the exploitation of the fabricated materials in this field.
Highlights
Superparamagnetic iron oxide nanoparticles (MNPs) have been the subject of great interest in recent years due to their various potential applications in biomedicine [1], electronics [2] or analytical chemistry [3]
We investigated whether the polyrhodanine coating (PRHD) and PRHD@MnFe2O4 hybrids affect proliferative as well ofasPRHD
It was shown that the average particle size does not increase significantly upon nanoparticle suspension in water media, the PRHD can act as a modifying agent preventing particle aggregation
Summary
Superparamagnetic iron oxide nanoparticles (MNPs) have been the subject of great interest in recent years due to their various potential applications in biomedicine [1], electronics [2] or analytical chemistry [3]. Particular attention was paid to well-known magnetic hyperthermia, photothermal therapies or emerging combination of both of them by taking advantage of synergic action of the alternating magnetic field and near infra-red light radiation (NIR) [4,5,6]. Resonance Imaging (MRI) [7] These advantages make MNPs unique and attractive for tumor targeting therapy [8], targeted drug delivery [9] and imaging [7]. Polymers 2020, 12, 2934 is relatively new and a lot of attention is directed towards this application. It is especially attractive for the shallow and on-skin non-invasive treatment as well as heat triggered drug delivery [10]
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