Abstract
Combination therapy has become an effective strategy for tumor treatment, but the preparation of drug nanocarriers with the high requirements still lacked exploration. In this paper, hollow shell-layer mesoporous polydopamine (HMPDA) was constructed on Fe3O4 nanoparticles (the magnetic core), and small-sized G5-Au nanoparticles (AuNPs) as the releasable satellite carriers for tumor deep treatment were modified on HMPDA surface, then the nucleus-satellite Fe3O4@HMPDA@G5-Au nano drug delivery carriers were obtained. The therapy drug could be loaded in the mesoporous structure of HMPDA and G5-Au nanoparticles, so the drug loading capacity was relatively large. The Fe3O4@HMPDA@G5-Au composite nano carriers also had good photothermal properties, because polydopamine (PDA) and AuNPs were both good photothermal agents. Combination of photothermal therapy (PTT) and drug therapy could significantly enhance the ablation of tumor cells with minor side effects. In addition, the decomposition of H2O2 in the tumor site catalyzed by the AuNPs could also produce oxygen to alleviate tumor hypoxia. In addition, because of the magnetic properties of Fe3O4 nanoparticles, the Fe3O4@HMPDA@G5-Au nano drug delivery carriers also had magnetic targeting performance and could reach the specified position under the guidance of external magnetic field. The results showed that the average DOX loaded amount of the prepared carriers was 473.83 mg/g, the drug release rate in 24 h could achieve 61.3 %. The cytotoxicity test showed that the drug loaded carriers had a significant inhibitory effect on HepG2 cells. The drug-loaded core-satellite nanocarriers could play a good synergistic treatment effect on cancer under the multi effect synergy of PPT, drug therapy, magnetic targeting and pH-responsive drug release.
Published Version
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