Multidisciplinary treatment is necessary in glioblastoma with extracerebral metastases.

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While glioblastoma is the most common malignant brain tumor in adults, extracerebral manifestations are very rare in this highly aggressive disease with poor prognosis. We conducted asystematic literature review in the PubMed database and complemented the data by inclusion of acase treated in our clinic. In this context, we report on a60-year-old woman with aright frontal glioblastoma, IDH wildtype, MGMT methylated. Six months after initial diagnosis and primary treatment, there was extensive local intracranial progression with additional extension into the subcutaneous and frontotemporal cranial bones. Despite continuation of multimodal treatment, further extracerebral manifestations occurred 11months after the initial diagnosis, both in the cranial bone as well as metastases in the right parotid gland, cervical lymph nodes, and lungs. While local radiotherapy enabled the cerebral lesions to be controlled, the patient's clinical condition deteriorated rapidly despite simultaneous systemic therapy. The treatment had to be discontinued, and the patient died 5weeks after confirmation of the multilocal extracerebral manifestations and atotal of 12months after initial diagnosis. Extracerebral manifestations of glioblastoma require close collaboration and joint decision-making with the patient, with an emphasis on palliative strategies.