Abstract
Jason Bodily works in the field of tumor virology. In this mSphere of Influence article, he reflects on how "Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion" by Adam Pickard et al. (EMBO J 31:3092-3103, 2012, https://doi.org/10.1038/emboj.2012.153) has impacted his work by making him think about the role of stromal cells in human papillomavirus infections.
Highlights
My training in tumor virology has focused how human papillomaviruses (HPVs) coordinate the virus life cycle in a differentiating epithelium
Commentary likely to be keenly important to the life cycle of HPV
Pickard et al did not study the role of stromal Rb in productive HPV infection, it was clear from their findings that HPV was almost certain to respond to signals from the stroma in the course of its infectious cycle
Summary
My training in tumor virology has focused how human papillomaviruses (HPVs) coordinate the virus life cycle in a differentiating epithelium. July/August 2019 Volume 4 Issue 4 e00467-19 The views expressed in this article do not necessarily reflect the views of the journal or of ASM.
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