Abstract
MPP + has been reported to inhibit reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase in mitochondria, which results in the formation of O 2 .−. The current report demonstrates that H 2O 2 and HO . are also products of MPP + interaction with NADH dehydrogenase. It is possible that MPP . formation precedes the formation of some of these active oxygen species. Reducing equivalents for radical formation come from NADH. MPP + may be capable of interacting with submitochondrial particles at a site other than the rotenone site, which results in some formation of oxygen radicals. Plasma amine oxidase incubations with MPDP + resulted in O 2 .−, H 2O 2, and perhaps HO . formation. This is probably due to MPP . formation from the oxidation of MPDP +. This study presents new findings that indicate the potential importance of oxygen radical formation in mitochondria during MPTP toxicity.
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