MP19-12 PREDIABETES IN PRIMARY INFERTILE MEN – RESULTS FROM A CROSS-SECTIONAL STUDY

Abstract

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II1 Apr 2018MP19-12 PREDIABETES IN PRIMARY INFERTILE MEN – RESULTS FROM A CROSS-SECTIONAL STUDY Luca Boeri, Paolo Capogrosso, Eugenio Ventimiglia, Filippo Pederzoli, Walter Cazzaniga, Nicola Frego, Francesco Chierigo, Edoardo Pozzi, Massimo Alfano, Federico Dehò, Emanuele Montanari, Franco Gaboardi, Vincenzo Mirone, Francesco Montorsi, and Andrea Salonia Luca BoeriLuca Boeri More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Filippo PederzoliFilippo Pederzoli More articles by this author , Walter CazzanigaWalter Cazzaniga More articles by this author , Nicola FregoNicola Frego More articles by this author , Francesco ChierigoFrancesco Chierigo More articles by this author , Edoardo PozziEdoardo Pozzi More articles by this author , Massimo AlfanoMassimo Alfano More articles by this author , Federico DehòFederico Dehò More articles by this author , Emanuele MontanariEmanuele Montanari More articles by this author , Franco GaboardiFranco Gaboardi More articles by this author , Vincenzo MironeVincenzo Mirone More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.661AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Diabetes Mellitus (DM) can induce long-term damages, dysfunctions and failures of various organs, including male reproductive system. Previous studies showed the impact of DM on semen parameters, nuclear DNA fragmentation and chromatin quality. Conversely, the association between prediabetes (pDM), a precursor to diabetes characterised by impaired fasting glucose or tolerance, and reproductive function has been scantly analysed. We investigated the risk of prediabetes among men presenting for couple's infertility. METHODS Complete demographic, clinical and laboratory data from 536 primary infertile men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI; categorized 0 vs ≥1). Body mass index (BMI) was calculated and serum hormones were measured in all cases. Semen analysis was based on 2010 WHO reference criteria. Azoospermia was defined as the absence of sperm in 2 consecutive semen analyses. Men were defined as having pDM if they had: (i) fasting plasma glucose concentration from 100 mg/dL to 125 mg/dL; (ii) 2-h plasma glucose concentration in the 75 g oral glucose tolerance test from 140 mg/dL to 199 mg/dL, (American Diabetes Association 2015). Descriptive statistics and logistic regression analysis tested the association between pDM and hormonal and seminal characteristics in the whole cohort. RESULTS Overall, pDM was found in 58 (10.8%) patients. Men with pDM were older (p=0.03), had higher BMI (p<0.001) and lower total testosterone (p=0.04) and SHBG values (p=0.02) than those without pDM. Higher DFI scores (p=0.04) and a greater proportion of non obstructive azoospermia (NOA) (28.1% vs. 16.6%; p=0.033) were more frequent in patients with pDM than in those without pDM. Seminal parameters did not significantly differ between groups. At multivariable logistic regression analysis, FSH values (OR 1.12, p<0.001) and having pDM (OR 2.45, p=0.04) achieved independent predictor status for NOA, after accounting for age, BMI, genetic abnormalities, cryptorchidism and testicular volume. CONCLUSIONS Prediabetes was found in up to 10% of our cohort of primary infertile men. Men with pDM depicted a higher risk of NOA compared to those without pDM. Moreover, pDM men presented lower testosterone levels, and higher sperm DNA fragmentation rates than those without pDM. These findings corroborate previous results showing an overall impaired fertile status in patients with impaired glucose metabolism. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e248-e249 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Luca Boeri More articles by this author Paolo Capogrosso More articles by this author Eugenio Ventimiglia More articles by this author Filippo Pederzoli More articles by this author Walter Cazzaniga More articles by this author Nicola Frego More articles by this author Francesco Chierigo More articles by this author Edoardo Pozzi More articles by this author Massimo Alfano More articles by this author Federico Dehò More articles by this author Emanuele Montanari More articles by this author Franco Gaboardi More articles by this author Vincenzo Mirone More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...