PD29-09 TRIGLYCERIDE-GLUCOSE INDEX (TYG) IS ASSOCIATED WITH SPERM PARAMETERS AND SPERM DNA FRAGMENTATION IN PRIMARY INFERTILE MEN: A CROSS-SECTIONAL STUDY

Abstract

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II (PD29)1 Sep 2021PD29-09 TRIGLYCERIDE-GLUCOSE INDEX (TYG) IS ASSOCIATED WITH SPERM PARAMETERS AND SPERM DNA FRAGMENTATION IN PRIMARY INFERTILE MEN: A CROSS-SECTIONAL STUDY Luca Boeri, Paolo Capogrosso, Edoardo Pozzi, Luigi Candela, Federico Belladelli, Walter Cazzaniga, Giuseppe Fallara, Nicolò Schifano, Eugenio Ventimiglia, Daniele Cignoli, Gianmarco Colandrea, Massimo Alfano, Costantino Abbate, Francesco Montorsi, and Andrea Salonia Luca BoeriLuca Boeri More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Edoardo PozziEdoardo Pozzi More articles by this author , Luigi CandelaLuigi Candela More articles by this author , Federico BelladelliFederico Belladelli More articles by this author , Walter CazzanigaWalter Cazzaniga More articles by this author , Giuseppe FallaraGiuseppe Fallara More articles by this author , Nicolò SchifanoNicolò Schifano More articles by this author , Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Daniele CignoliDaniele Cignoli More articles by this author , Gianmarco ColandreaGianmarco Colandrea More articles by this author , Massimo AlfanoMassimo Alfano More articles by this author , Costantino AbbateCostantino Abbate More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002030.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Male factor infertility (MFI) is often associated with metabolic disorders such as diabetes mellitus and metabolic syndrome, where insulin resistance (IR) plays a relevant pathological role. The Homeostatic Model Assessment (HOMA) and triglycerides/glucose index (TyG) are a good marker of IR. We aimed to investigate the relationship between the TyG and both semen and hormonal characteristics in a cohort of primary infertile men. METHODS: Complete demographic, clinical and laboratory data from 726 consecutive primary infertile men (infertility defined according to the WHO definition) were considered. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). Serum hormone, semen analyses (based on 2010 WHO reference criteria) and sperm DNA fragmentation index (DFI) were measured in every patient. Glucose, insulin and triglycerides levels were measured after a 12-h overnight fast, and HOMA-IR and TyG indices were calculated and classified using a 2.6 threshold (as from Ascaso et al. 2003) and a 8.1 threshold (as from Kang et al. 2017), respectively. Descriptive statistics and logistic regression models tested the association between TyG with hormonal milieu and semen parameters. RESULTS: Median (IQR) age was 39 (35-43) years. A TyG and HOMA suggestive for IR was found in 339 (46.6%) and 154 (21.2%) patients, respectively and 121 (16.7%) had both. At Spearman’s test, TyG was correlated with HOMA-IR score (rho = 0.46, p<0.001). Compared to men with normal TyG, men with TyG>8.1 were older [37 (34-41) vs. 39 (35-43) years], had greater BMI [24.5 (23-27) vs. 26 (24-28) kg/m2] and CCI scores (0 vs 1), lower total testosterone [4.5 (3.4-5.6) vs. 4.2 (3.1-5.5)] and sperm concentration [8.0 (1.5-25.0) vs. 12 (2.8-30)], but higher DFI [38.2 (23-54) vs. 28.0 (18-48)] and presented a greater proportion of NOA (24.8% vs. 16.3%) (all p<0.01). At multivariable logistic regression analysis, men with TyG>8.1 were at higher risk of NOA [OR 1.78 (CI: 1.1-2.8)] and DFI>30 [OR 1.92 (CI: 1.2-2.9)], after accounting for patient age, CCI, FSH values, and testicular volume. CONCLUSIONS: Patients with TyG suggestive for IR showed worse clinical, hormonal and semen parameters compared to those with lower TyG values. TyG index represents a reliable marker of IR for primary infertile men in the real-life setting, thus supporting an easier long-term follow-up of patients at higher risk of chronic dysmetabolic comorbidities. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e530-e530 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Luca Boeri More articles by this author Paolo Capogrosso More articles by this author Edoardo Pozzi More articles by this author Luigi Candela More articles by this author Federico Belladelli More articles by this author Walter Cazzaniga More articles by this author Giuseppe Fallara More articles by this author Nicolò Schifano More articles by this author Eugenio Ventimiglia More articles by this author Daniele Cignoli More articles by this author Gianmarco Colandrea More articles by this author Massimo Alfano More articles by this author Costantino Abbate More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement Loading ...