Morphological substantiation of the use of laser and led irradiation in emergent treatment of ulcer complications

doi:10.26565/2076-0612-2018-24-06

Abstract

The structural basis of ulcer perforation and bleeding was determined, based on morphological evaluation of gastroduodenal ulcers. The effects of low-intensive laser irradiation LILI and LED irradiation on pathomorphosis of ulcers were studied. It was found that the local phototherapy with LILI and LED increases the relative fraction volume — RFV of fibroblasts and connective tissue fibers, reduces RFV of cell-free zones, which contributes to “strengthening” of the ulcer walls and prevents their perforation. These same photo-infllead to an increase of RFV of blood vessels, indicating inappropriateness of their use for local phototherapy in bleeding ulcers.

Highlights

Background and objectivesMarked trend in decrease of the number of patients with peptic ulcer disease requiring surgical treatment, due to the development of the “gold standard” of drug therapy of this disease, based on the discovering etiological and pathogenetic role of Helicobacter pylori. [1,2,3,4]Despite this, peptic ulcer disease — PUD continues to be one of the most urgent problems of surgery
Various types of photo-influencing such as local irradiation of ulcers, using low-intensive lasers — LIL, and more recently, LED (Light Emitting Diode) light and intravascular laser irradiation of blood — ILIB widely used in gastroenterology, including complex treatments of urgent complications of ulcers. [1,7,13-18]
Studies show that, as a rule, the efficiency of LILI is comparable to LED. [1,13,14,15,18] Gastroenterology, in this respect, is no exception

Summary

Introduction

Background and objectivesMarked trend in decrease of the number of patients with peptic ulcer disease requiring surgical treatment, due to the development of the “gold standard” of drug therapy of this disease, based on the discovering etiological and pathogenetic role of Helicobacter pylori. [1,2,3,4]Despite this, peptic ulcer disease — PUD continues to be one of the most urgent problems of surgery. A significant proportion of patients with PUD need emergent treatment. This is especially true of its complicated forms. Morphological grounds of expediency of using particular types of photo-influencing and methods for their use in the treatment of urgent complications of ulcers are not clear enough. This has determined the objectives of study: to provide morphological justification for reasonability of using LIL and LED in complex treatment of bleeding and perforations of gastroduodenal ulcers This is especially true of its complicated forms. [2,3,5,6,7,8,9,10,11,12]

Methods

Results

Conclusion