Abstract
The actual problem of modern medicine is the reaction of Bronchus associated lymphoid tissue in airways chronic allergic diseases, because the full functioning of the respiratory system depends on the state of its local immune system.
 The aim – to study morphological changes in Bronchus associated lymphoid tissue of guinea pigs in the dynamics of experimental ovalbumin-induced allergic inflammation.
 Material and Methods. We have studied the lung of 48 guinea pigs, using histological and morphometric methods, under conditions of experimental ovalbumin-induced allergic inflammation. To assess the structural and functional rearrangement of pulmonary lymphoid nodules, their diameter and number were determined.
 Results. We have shown that sensitization and allergization with ovalbumin leads to a significant structural and functional rearrangement of Bronchus associated lymphoid tissue of guinea pigs in the form of the elevation in their number and diameter. We found more pronounced morphological changes in the late period of development of allergic inflammation in peribronchial lymphoid nodules, confirmed by the maximum magnification factor – 2.6 (p*/**<0.001) of the diameter of peribronchial lymphoid nodules in the 4th experimental group compared to the control.
 Conclusions. Sensitization and inhalation with ovalbumin leads to structural reorganization of Bronchus associated lymphoid tissue of guinea pigs in the form of the elevation in their number and diameter, had the unidirectional staged character depending on localization of lymphoid nodules and the duration of the experiment and claimed proliferative changes in the cellular adaptive link of local lung immunity of guinea pigs in late period of allergic inflammatory process.
Highlights
The organs of the immune system consist of lymphoid tissue, which is the "working" parenchyma of the organs of immunogenesis, can be diffuse and in the form of Mucosa associated lymphoid tissue and defends the constant state of the internal environment of the body throughout the life of the individual [1–3]
We have shown that sensitization and allergization with ovalbumin leads to a significant structural and functional rearrangement of Bronchus associated lymphoid tissue of guinea pigs in the form of the elevation in their number and diameter
We found more pronounced morphological changes in the late period of development of allergic inflammation in peribronchial lymphoid nodules, confirmed by the maximum magnification factor – 2.6 (p*/**
Summary
The organs of the immune system consist of lymphoid tissue, which is the "working" parenchyma of the organs of immunogenesis, can be diffuse and in the form of Mucosa associated lymphoid tissue and defends the constant state of the internal environment of the body throughout the life of the individual [1–3]. The cellular component of Bronchus associated lymphoid tissue is represented by immunocompetent cells: first of all, small lymphocytes, as well as plasma cells, included in the immune process, ensure the recognition and destruction of inhaled foreign substances carried signs of genetically foreign information by T- and B-lymphocytes, which function together and with the participation of macrophages provide immune response in the body [4–7]. Proceeding from the importance of Bronchus associated lymphoid tissue, there is a need for a detailed study of it in the dynamics of allergic inflammatory process, it is of current importance for the search for new methods of its correction. The aim of this work is to study morphological changes in Bronchus associated lymphoid tissue of guinea pigs in the dynamics of experimental ovalbumin-induced allergic inflammation
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