Abstract
Background: Candida albicans are normal flora in the oral cavity and can turn into pathogens. Antifungal drugs need to be given to inhibit the growth of the fungus; using traditional medicine, for example moringa seeds. Moringa seeds contain natural compounds like polyphenols and flavonoids as an antifungal.Objective: To determine the inhibition of Moringa oleifera L. seed extract on the growth of C.albicans. Method: This experimental laboratory research was designed with posttest only control group with agar/Kirby Bauer diffusion method, carried out with 4 repetitions by treated extract with 40%, 60%, 80%, 100% concentration, positive control (ketoconazole) and negative controls (distilled water). Results: Krusskal Wallis test showed p value = 0.000 (p <0.05),means Moringa seed extract with concentrations 40%, 60%, 80%, 100% had a significant effect on inhibiting the growth of C.albicans. Conclusion: Moringa seed extract can inhibit the growth of Candida albicans.
Highlights
Candida albicans are normal flora in the oral cavity and can turn into pathogens
Antifungal drugs need to be given to inhibitthe growthof the fungus;usingtraditional medicine
Moringaseedscontainnatural compounds like polyphenols and flavonoids
Summary
Buah kelor yang masih segar sebanyak 300 g dikeringkan di udara selama 7 hari, digiling menjadi bubuk sehingga diperoleh simplisia sebanyak 150 g. Pembuatan suspensi jamur Candida albicans Alat-alat yang digunakan untuk uji disterilkan dengan menggunakan autoklaf pada suhu 1210 C selama 20 menit. Bentuk cair dari isolat murni C.albicans diperoleh dariLaboratoriumMikrobiologiFakultas Kedokteran UniversitasHasanuddin.Suspensi jamur ini diperoleh dengan mengambil jamur C.albicans menggunakan satu lidi kapas steril dan dimasukkan ke dalam tabung reaksi yang berisi larutan NaCl 0,9% sebanyak 3 mL kemudian dicampur hingga homogen sampai cairan menjadi keruh sesuai standar kekeruhan McFarland 0,5%. Selanjutnya, kertas cakram yang telah direndam di dalam larutan sampel ekstrak biji kelor, kontrol positif dan negatif selama 15 menit ditempatkan pada permukaan media agar yang telah diinokulasi jamur uji menggunakanpinsetsteril.Setelahitubaru masingmasing kertas cakram diletakkan di atas media agar. Data dianalisis menggunakan uji Kruskall Wallis untukmelihatperbandinganrata-rata zona daya hambat yang terjadi pada setiap konsentrasi ekstrak biji kelor terhadap pertumbuhan jamur C.albicans.Selanjutnya.
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