Moringa oleifera, Lam. Seeds as Traditional Herbal Medicine for Liver Inflammation of Metabolic Syndrome Rats (Rattus Norvegicus)

Abstract

Introduction: Metabolic syndrome is a condition where the levels of sugar, cholesterol and fat are very high in the body that characterized by the occurrence of central obesity. Metabolic syndrome has been associated with chronic inflammation due to the increased production of reactive oxygen radical that impact on the increasing of mediator of inflammation. Liver is the main organs to metabolize fats and sugar, so liver has the biggest impact of metabolism result. Moringa seeds as traditional herbal contain plenty of secondary metabolites rich in antioxidants. This research aimed to determine the effect of Moringa seeds ethanolic extract to liver inflammation of metabolic syndrome rats. Methods: This was laboratory experimental research using posttest only group design. Rats were divided into 4 groups: K1 were control group, K2 were metabolic syndrome rats model, K3 were metabolic syndrome rats model and given Moringa seeds extract dose 150mg/KgBW, K4 were metabolic syndrome rats model and given Moringa seeds extract dose 200mg/KgBW. The metabolic syndrome induced by duck yolk 2ml/200gBW, oxidized oil 1ml/200gBW, beef tallow 2ml/200gBW and fructose 0,36ml/200gBW for 53 days and Moringa seeds extract as intervention was given 28 days. Effect of moringa seeds extract to liver inflammation were analyzed Kruskal-Wallis test continued with Mann-Whitney Test. Result: Kruskal-Wallis test of liver inflammation showed that there were significant differences (p＜0,05), whereas Mann-Whitney test showed there were significant differences of liver inlammation between K1-K2, K2-K3, and K2-K4 (p＜0,05). Conclusions: Moringa oleifera seeds extract at a dose of 150mg/KgBB and a dose of 200mg/KgBB could decrease and repair liver inflammation significantly in metabolic syndrome rats.