Abstract
The magnetic targeting drug delivery system is an effective way of targeting therapy. In this study, the monodisperse Fe3O4 nanoparticles with a particles size of about 180 nm were first prepared via a solvothermal method. Subsequently, the core-shell structure Fe3O4/SiO2 and Fe3O4/SiO2/polypyrrole (PPy) composite nanospheres were successfully synthesized by coating Fe3O4 nanoparticles with SiO2 shell layer using the Stöber method and PPy shell by solvothermal method in turn. The as-prepared nanoparticles were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA), and Ultraviolet-Visible spectrophotometer (UV-Vis). The results indicated that the as-prepared composite nanospheres displayed a well-defined core-shell structure and monodispersity. The thicknesses of SiO2 shell and PPy shell were ~6 nm and ~19 nm, respectively. Additionally, the as-prepared nanoparticles exhibited high saturation magnetization of 104 emu/g, 77 emu/g, and 24 emu/g, and have great potential applications in drug delivery. The drug loading and drug release of the Fe3O4/SiO2 and Fe3O4/SiO2/PPy composite nanospheres to ibuprofen (IBU) under stirring and ultrasonication were investigated. Their drug loading efficiency and drug release efficiency under ultrasonication were all higher than 33% and 90%, respectively. The drug release analyses showed sustained release of IBU from nanospheres and followed the Korsmeyer-Peppas model.
Highlights
Ibuprofen (IBU) is the most commonly used and most frequently prescribed non-steroidal anti-inflammatory drug to relieve inflammation, fever, and pain from headache, migraine, toothache, joint pain, back pain, muscle pain, and menstrual cramps through oral administration [1,2,3,4]
Fe3 O4 /SiO2 /PPy composite nanospheres to ibuprofen (IBU) under stirring and ultrasonication were investigated. Their drug loading efficiency and drug release efficiency under ultrasonication were all higher than 33% and 90%, respectively
The drug delivery system can be used to deliver IBU directly to the infected site through parenteral route [5,6], and as the molecular size of IBU is only 0.6–1 nm, which is suitable to be connected to the nano-drug carrier [7,8,9], this makes it an ideal candidate for use in controlled release drug delivery systems
Summary
Ibuprofen (IBU) is the most commonly used and most frequently prescribed non-steroidal anti-inflammatory drug to relieve inflammation, fever, and pain from headache, migraine, toothache, joint pain, back pain, muscle pain, and menstrual cramps through oral administration [1,2,3,4]. Due to the extremely poor water solubility, oral administration can stimulate the gastrointestinal tract, produce side effects such as chest pain, headache, and vomiting, and in severe cases, can cause gastric bleeding, which limits the maximum daily dosage To overcome these shortcomings, the drug delivery system can be used to deliver IBU directly to the infected site through parenteral route [5,6], and as the molecular size of IBU is only 0.6–1 nm, which is suitable to be connected to the nano-drug carrier [7,8,9], this makes it an ideal candidate for use in controlled release drug delivery systems. Silica/mesoporous silica nanoparticles are non-toxic, biocompatible, biologically inert, and have strong stability even at
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