Research progress of static magnetic field targeting drug delivery system in tumor diagnosis and therapy

Abstract

Chemotherapy is one of the traditional tumors treatment solutions. Chemotherapy has the feature of tissue non-specificity, which can cause side effects on normal cells while inhibiting tumor cell growth. Magnetic targeting drug delivery system (MTDDS) employs biocompatible and stable magnetic nanoparticles (MNP) as drug carries to transport and accumulate anticancer drugs to the specific tumor tissues under the guidance of external magnetic field. This technology not only improves the efficiency of drug delivery and antitumor activity, but also reduces the drug dosage and side effects. The properties of drug-loaded MNPs and the applied external magnetic field are the main factors that affecting the MNPs targeting to the tumor tissues. The effectiveness of the targeted delivery of the drug-loaded magnetic nanoparticles mainly depends on the form and strength of the magnetic field at the target site. That is, whether there is sufficient strength to attract and retain NMPs, and to promote antitumor drug release at the tumor region. In this paper, the research progress of static magnetic field targeting drug delivery system in tumor diagnosis and therapy was summarized, which can provide some basic information for the relative scientific researches. Key words: Magnetic nanoparticles; Magnetic targeting drug delivery system; Static magnetic field; Tumor diagnosis and therapy