Evaluation of drug release efficiency and antibacterial property of a pH-responsive dextran-based silver nanocomposite hydrogel

Abstract

The bioavailability of curcumin (CUR), a highly lipophilic and commonly used anticancer drug, is mainly affected by its poor solubility in aqueous environment and quick metabolism. These challenges can be met by employing delivery systems. Nanocomposite materials have been used as delivery systems to enhance the solubility and dissolution rate of the drug. This study aims to develop dextran-graft-poly(4-acryloylmorpholine) silver nanocomposite using a microwave-assisted method to evaluate its drug-release efficiency and antimicrobial activity. The materials were characterized by FT-IR, FE-SEM, EDS, XRD, HR-TEM, TGA, and BET techniques. Drug loading and release efficiency were evaluated using CUR as the model drug. The swelling and drug release studies were conducted in buffer solutions of pH 1.2 and 7.4. Staphylococcus aureus and Escherichia coli were employed to evaluate the antibacterial activity. The cytotoxicity was assessed by MTT assay against the breast MCF-10. Higher swelling and drug release were observed at pH 1.2 than 7.4. Nanocomposite hydrogel exhibited antibacterial activity against the tested bacterial strains. Cytotoxicity study proved the safety of the developed matrix. The results suggest the developed nanocomposite hydrogel to be a promising polymer matrix for the sustained release of CUR for cancer treatment that requires infectious control.