Abstract
Background: Systemic lupus erythematosus (SLE) is a relatively uncommon disease of young females in Pakistan. Usually, it has a relapsing-remitting course with variable severity and disease activity. Amongst the different clinical and laboratory parameters used to monitor disease activity in lupus, mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. This study included 25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLE disease activity index (SLEDAI) and erythrocyte sedimentation rate (ESR). Independent sample t-test and Pearson's correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis. Results: The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant ( P<0.001). MPV had an inverse relationship with both ESR (r=-0.93, P<0.001) and SLEDAI (r= -0.94, P<0.001). However, there was a strong positive correlation between ESR and SLEDAI (r=0.95, P<0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% ( P< 0.001). Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV.
Highlights
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can affect any organ system of the body
This study was approved by the Ethics Review Committee of the hospital and a written informed consent was obtained from every participant
The clinical features of patients with active- and inactive-SLE are shown in Table 1 and Table 2, respectively
Summary
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can affect any organ system of the body It has an annual incidence of 5 per 100,000 of the general population[1]. There are racial and ethnic variations, with higher rates reported in Black and Hispanic peoples[2] This disease with protean manifestations has a remitting relapsing course; it has a tendency to vary from acutely progressive to chronic indolent forms[1,2]. Systemic lupus erythematosus (SLE) is a relatively uncommon disease of young females in Pakistan. It has a relapsing-remitting course with variable severity and disease activity. MPV was correlated with SLE disease activity index (SLEDAI) and erythrocyte sedimentation rate (ESR). Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV
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