Abstract
Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study. On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively;25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). Independent sample t-test and Spearman's rho and Pearson's correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis. Results: The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant ( P<0.001). MPV had an inverse relationship with both ESR (r=-0.93, P<0.001) and SLEDAI (r s= -0.89, P<0.001). However, there was a strong positive correlation between ESR and SLEDAI (r s=0.90, P<0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% ( P< 0.001). Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV.
Highlights
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can affect any organ system of the body
We performed the present study to find out whether mean platelet volume (MPV) does or does not correlate with systemic lupus erythematosus (SLE) disease activity index (SLEDAI) and whether it can be used a predictor of lupus severity and activity. Patient characteristics This cross-sectional study was conducted in the Department of Medicine of Khyber Teaching Hospital (KTH; Peshawar, Pakistan) between January 2015 and July 2016
This study was approved by the Ethics Review Committee of the hospital and a written informed consent was obtained from every participant
Summary
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can affect any organ system of the body. It has an annual incidence of 5 per 100,000 of the general population[1]. There are racial and ethnic variations, with higher rates reported in Black and Hispanic peoples[2] This disease with protean manifestations has a remitting relapsing course; it has a tendency to vary from acutely progressive to chronic indolent forms[1,2]. Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Sensitivity and specificity of MPV were checked through ROC analysis
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