Abstract
Molecular modelling studies show that an anthraquinone attached to an oligodeoxynucleotide containing protonated cytosine bases stabilizes triple helix formation with the target DNA sequence. Furthermore, the anthraquinone moiety preferentially adopts a parallel intercalative binding mode at the triplex–duplex junction. Modelling also shows that the triple helix stabilization is enhanced in the presence of endogenous polyamines such as spermine.
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