Abstract

A number of anthraquinones have been synthesized and linked to a 10-mer homopyrimidine oligodeoxynucleotide. All the anthraquinone-oligodeoxynucleotide conjugates exhibited sequence specific triple helix formation when tested by DNase I footprinting. Neither the presence of an ionizable side chain nor the position of substitution of the anthraquinone appeared to affect triplex stability.

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