Abstract
Abstract In the oral cavity, oncogenesis is widely believed to result from cumulative genetic alterations that cause a transformation of the mucosa from normal to dysplastic to invasive carcinoma. However, all epithelial dysplasias do not develop into cancer and some have shown to regress with time. Many potential markers have been used to diagnose the epithelial dysplasia and to predict their transformation into carcinoma such as p53 targets and family members: p53, MDM2, p16, p63, Akt. Therefore, identification of molecular and cellular markers specific to the oral lesions with potentially malignant transformation could lead to early detection, accurate diagnosis, prevention of the development of oral squamous cell carcinoma (OSCC). The present review highlights on a series of molecules markers that are reported to be significantly associated with progression of oral epithelial dysplasia to OSCC and are considered as potential biomarkers in predicting malignant transformation of epithelial dysplasias into OSCC.
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