Abstract
Orthodontic treatment is associated with pain, difficulty in plaque control, caries incidence, and slow movement of teeth. Authors hypothesize that the answer to these questions may lie in phytochemicals which are a huge unexplored area. Due to previous reports on Adhathoda vasica about its anti-inflammatory and antimicrobial properties, its use in orthodontics is explored in the dry lab scenario. This can be considered as a preliminary step to study the herb in great detail for use in orthodontic therapy. Computational algorithms from Auto Dock version 4 were used in the study. Vasicine, Vasinone, Vasicoline and Anisotine were analysed against Glucosyltransferase (GFT) of Streptococcus mutans, Gingipain K - Porphyromonas gingivalis, FIM A of Porphyromonas gingivalis, TNF ALPHA and Prostaglandin H synthases. Compounds exerted promising inhibiting action against Streptococcus mutans, Gingipain K, FimA, TNF-alpha and prostaglandin E2. The said phytochemicals - Vasicine, Vasicinone, Vasicoline and Anisotine can further be explored for proper delivery to saliva, periodontal region and to bone for effective use during and after orthodontic treatment.
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