Abstract
pH dependent hydrogels of modified tamarind kernel polysaccharide (TKP) were synthesized by grafting with polyacrylamide chains on TKP backbone in presence of microwave irradiation and initiator. The present study is carried out to design oral controlled drug delivery systems for aspirin using synthesized hydrogels as carrier in form of tablets. TKP-g-PAM based hydrogels show significant enhancement for control release of aspirin. Release behavior of aspirin has been evaluated using USP type I apparatus in 900mL of buffer solutions (pH 1.2, 6.8, 7.4), maintained at 37°C at 100rpm. It is observed that with increase in percentage of grafting (% G), swelling of matrices increases whereas erosion and rate of drug release decrease. The effect of % G onto t50 value (time taken for release of 50% drug) has also been discussed. The release characteristics from the matrices under study show non-Fickian diffusion mechanism, suggesting the controlled release of aspirin.
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