Abstract
Objectives: The objective is to compare the new short protocol with traditional short protocol in ICSI programs. Study design: Controlled trial. Materials and methods: 40 cases scheduled for ICSI after a variable period of infertility classified into two groups according to stimulation protocol. group1(20 case) with fixed 2 dose regimen (given merional ampoules) 4 ampoules first four days of stimulation the 3 ampoules thereafter while the other 20 patients given the traditional short protocol starting with 3 ampoules then dose adjusted according to patient response. Results: Days of stimulation, Number of merional ampoules, were significantly less in the new modified short protocol than in the classic short protocol; while number of M2 oocytes, number of good embryos, pregnancy rate were significantly high in the group 1. Pregnancy rate was 75% in the new modified protocol and 50% with the classic short protocol. Conclusion: The new short fixed 2 dose short protocol regimen offers a benefit in all the ways in ICSI success and pregnancy rate with less time of gonadotropin stimulation and less cost.
Highlights
The new short fixed 2 dose short protocol regimen offers a benefit in all the ways in intracytoplasmic sperm injection (ICSI) success and pregnancy rate with less time of gonadotropin stimulation and less cost
During IVF treatment the primary aim of Controlled Ovarian Hyper-Stimulation (COH) using gonadotrophin injections is to stimulate the development of several mature oocytes, rather than a solitary oocyte that would develop in an unstimulated “natural” cycle
In meta-analyses of the effectiveness of hMG and r-FSH in IVFICSI cycles, it became evident that hMG treatment resulted in a higher clinical pregnancy rate and in higher ongoing pregnancy and live birth rates than did r-FSH, but the latter difference was of borderline significance [6]
Summary
During IVF treatment the primary aim of Controlled Ovarian Hyper-Stimulation (COH) using gonadotrophin injections is to stimulate the development of several mature oocytes, rather than a solitary oocyte that would develop in an unstimulated “natural” cycle.Because of the considerable natural attrition that occurs during IVF treatment (failed fertilization, poor embryo development), this COH approach maximizes the chances of producing good quality embryos available for transfer or cryopreservation, thereby boosting pregnancy rates.The production of less than five oocytes has been shown to significantly reduce a woman’s chances of a live birth [1,2] while the development of more than 15 oocytes places her at considerable risk of potentially dangerous Ovarian Hyper-Stimulation Syndrome (OHSS).Three decades after the birth of the first IVF baby, poor response to ovarian hyperstimulation still remains a frustrating limiting factor for IVF programs throughout the developed world.The “standard” approach to predicting a patient’s response to COH has been based on age and early follicular phase FSH levels. During IVF treatment the primary aim of Controlled Ovarian Hyper-Stimulation (COH) using gonadotrophin injections is to stimulate the development of several mature oocytes, rather than a solitary oocyte that would develop in an unstimulated “natural” cycle. Because of the considerable natural attrition that occurs during IVF treatment (failed fertilization, poor embryo development), this COH approach maximizes the chances of producing good quality embryos available for transfer or cryopreservation, thereby boosting pregnancy rates. The production of less than five oocytes has been shown to significantly reduce a woman’s chances of a live birth [1,2] while the development of more than 15 oocytes places her at considerable risk of potentially dangerous Ovarian Hyper-Stimulation Syndrome (OHSS). The “standard” approach to predicting a patient’s response to COH has been based on age and early follicular phase FSH levels. Good prognosis patients (age 36 years, elevated FSH, one ovary) are started on 200 - 300 IU/day of FSH [3]
Sign-in/Register to view highlights & summary 
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call