Abstract
Subcutaneous administration of thyrotropin-releasing hormone (TRH) prior to and during morphinization inhibited the development of dependence on morphine in mice. This was evidenced by inhibition of the hypothermic response observed during abrupt and naloxone precipitated withdrawal. Naloxone precipitated withdrawal jumping response was not inhibited by TRH. Intracerebral injection of TRH in morphine-dependent mice inhibited the naloxone precipitated withdrawal jumping as well as hypothermia. Subcutaneous injection of TRH in mice after dependence had developed partially antagonized the hypothermic response for 3 to 4h. However, TRH was without effect in placebo pellet implanted mice. It is concluded that TRH can block abstinence syndrome in morphine dependent mice when injected icv and also inhibit the development of physical dependence on morphine. Studies with peripheral administration of TRH indicate that sites initiating abstinent jumping response and those affecting temperature regulation during abstinence may not be the same.
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