Abstract
The density of opiate and neuroleptic receptors were measured in control and schizophrenic brain tissue. An increased density of neuroleptic receptors were detected in the neostriatum of schizophrenic brain tissue. Decreased levels of opiate receptors were observed in the schizophrenic caudate nucleus, but normal levels were found in the schizophrenic putamen and frontal cortex. In addition, a metabolite of des-tyr-γ-endorphin, β-LPH(66-77) has been demonstrated to interact directly with neuroleptic receptors. These results are discussed in terms of their possible relationship to the pathophysiology of schizophrenia.
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