Modern integrated approach in the treatment of atrophic vaginitis in women of menopausal age

Abstract

The objective: to evaluate the clinical effectiveness of treatment of atrophic vaginitis in menopausal women using combined therapy, which includes vaginal suppositories with hyaluronic acid. Materials and methods. A clinical and laboratory examination of 60 women 50-65 years old with atrophic vaginitis was carried out. The main group (30 patients) received combined therapy: a combination of local estrogen with intravaginal insert of a drug with hyaluronic acid. The patients of the control group (30 women) received only local therapy with estrogens.Results. Clinical and laboratory remission after the treatment was determined in 100 % of women in the main group and 63.3 % of patients in the control group (p<0.05). At the same time, the clinical effect was observed earlier in persons in the main group compared to the women in the control group. After treatment, the range of Nugent scores in all women of the main group ranged from 0 to 3 points, in the control group a normal state of biocenosis was diagnosed in 53.3 % of patients, an intermediate state – 20 %, in 26.7 % of women Nugent criteria ranged from 6 to 10 points. In 2 months after the end of therapy, 86.7 % of patients in the main group and 53.3 % of women in the control group had the high effectiveness of the treatment (p<0.05). In 46.7 % of women in the control group, the recurrences of the disease were determined, which required a repeated course of therapy. Only in 13.3 % of patients in the main group, manifestations of atrophic vaginitis were observed. Conclusions. The conducted study proves the high efficiency of suppositories containing hyaluronic acid in the complex treatment of atrophic vaginitis in women of menopausal age, which prolong the inter-recurrence period and reduce the severity of the clinical symptoms of disease recurrences.