Modelling Of PAFC Based Scattering Monitoring System for the Characterization of the Therapeutic Micro-Bubbles

Abstract

In recent years, researchers are eagerly developing the Ultrasound Cavity Agents (UCA) as a therapeutic agent, so that they can deliver the drugs to an intended place in a guided manner with minimal invasiveness and maximum effectiveness. However, control dissolution of the drug is still an issue because the shell of the micro-bubble sometimes collapses instantaneously and start releasing the drug at a faster rate. This sudden rise in the pressure's level can rupture the capillaries and sometimes blood vessels also. Therefore, in such cases, it is a great challenge to examine the dynamics of the micro-bubble as well as the health of the blood vessel. In this essence, this paper presents a study based on the finite element method to examine the potential use of Photo-Acoustic Flow Cyclometery (PAFC) to resolve this issue. The presented model is based on the study of the intensity variations of the optical scatterings engender by the micro-bubbles through PAFC. The results of the study reveal that the proposed model has the potential to be used as a new mechanism to examine the growth of the micro-bubble as well as the health of the blood vessel. Moreover, by analysing the scattering pattern, one can also able to predict the value of the cavitation threshold and the size of the micro-bubble. Hence, the authors envisioned that the modified PAFC system can lead the path of a low-cost and real-time examiner for accurate target drug delivery as well as for the health of the blood vessel. Which in turn potentially increases the localized concentration of the drug to reduce the concerned side-effects of medicine on the other part of the body.