Abstract
Nowadays, mild hypothermia is widely used in the fields of post-cardiac arrest resuscitation, stroke, cerebral hemorrhage, large-scale cerebral infarction, and craniocerebral injury. In this paper, a locally mixed sub-low temperature device is designed, and the cold and hot water mixing experiment is used to simulate the human blood transfer process. To set a foundation for the optimization of the heat transfer system, the static characteristics are analyzed by building the mathematic model and setting up the experimental station. In addition, the affection of several key structure parameters is researched. Through experimental and simulation studies, it can be concluded that, firstly, the mathematical model proved to be effective. Secondly, the results of simulation experiments show that 14.52 °C refrigeration can reduce the original temperature of 33.42 °C to 32.02 °C, and the temperature of refrigerated blood rises to 18.64 °C, and the average error is about 0.3 °C. Thirdly, as the thermal conductivity of the vascular sheath increases, the efficiency of the heat exchange system also increases significantly. Finally, as the input cold blood flow rate increases, the mass increases and the temperature of the mixed blood temperature decreases. It provides a research basis for subsequent research on local fixed-point sub-low temperature control technology.
Highlights
Mild therapeutic hypothermia has been widely used in the treatment of post-cardiac resuscitation, stroke, cerebral hemorrhage, large-area cerebral infarction and craniocerebral injury [1,2,3,4]
The results show that selective brain hypothermia can significantly reduce secondary brain damage and brain edema in cerebral ischemia and experimental brain injury animals, which can reduce harmful substances and protect nerve function and improve survival rate [26,27,28,29]
6 Conclusions In this study, to set a foundation for the follow-up work on local fixed-point hypothermia control technology, a mathematical model of the blood heat transfer was proposed, and its static characteristics are analyzed by researching the key parameters of great influence
Summary
Mild therapeutic hypothermia (refers to deliberate reduction of the core body temperature, typically to a range of 32 °C to 34 °C) has been widely used in the treatment of post-cardiac resuscitation, stroke, cerebral hemorrhage, large-area cerebral infarction and craniocerebral injury [1,2,3,4]. The experimental study found that the time to reach the sub-low temperature through the body surface cooling is 7.0 ± 2.6 h, and the rewarming time is 8.2 ± 0.8 h, at the same time, the time to reach sub-low temperature by intravascular heat exchange was only 4.8 ± 1.9 h, and the rewarming time was 6.0 ± 0.5 h. There is a need in the clinic for a treatment technique that can locally achieve and maintain a sub-hypotherm state to improve the effect of hypothermia treatment and reduce the complications caused by systemic cooling [30]. A local sub-hypotherm device that can achieve mixed cooling is designed to provide a research basis for the subsequent study of local fixedpoint sub-hypothermia control technology
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