Effect of mild hypothermia in prevention and treatment of cerebral vasospasm in patients with craniocerebral injury after operation

Abstract

Objective To observe the effect of mild hypothermia in prevention and treatment of cerebral vasospasm (CVS) in patients with craniocerebral injury after operation and its effect on prognosis. Methods 98 patients with craniocerebral injury were divided into control group and observation group by random number table method, 49 cases in each group. The control group was given conventional normothermia treatment, while the observation group was given mild hypothermia therapy. The mean velocity of middle cerebral artery (VMCA) on the postoperative 1st, 3rd, 5th, 7th d, the incidence of CVS, the severity of CVS, and the prognosis of patients were compared between the two groups. Results On the postoperative 1st d, there was no statistically significant difference in VMCA between the two groups (P>0.05); on the postoperative 3rd, 5th, 7th d, VMCA of the observation group were significantly lower than those of the control group (P<0.05). CVS was more severe in the control group than the observation group, and the incidence of CVS was significantly lower in the observation group (P<0.05). The excellent and good rate of prognosis was significantly higher in the observation group than the control group (P<0.05). Conclusion Mild hypothermia can reduce the incidence and severity of CVS and improve the prognosis of patients with craniocerebral injury. Key words: Mild hypothermia; Craniocerebral injury; After operation; Cerebral vasospasm