Clinical study on the intracranial hypertension after craniocerebral injury with Lishui-Huayu decoction

Abstract

Objectives To explore the effect of Lishui-Huayu decoction combined with mild hypothermia for the intracranial hypertension after craniocerebral injury. Methods A total of 80 patients with craniocerebral injury who met the inclusion criteria were randomly divided into 2 groups, 40 in each group. The control group was given mild hypothermia treatment, and the study group was treated with Lishui-Huayu decoction on the basis of the control group. Both groups were treated for 8 weeks. Continuous monitoring of ICP, Mean arterial pressure (MAP), Cerebral perfusion pressure (CPP), Central venous pressure (CVP) before and after treatment, recording ICP maximum reduction and time were observed. The Glasgow Outcome Scale (GOS) was used to evaluate the prognosis of patients. Results After treatment, the lowest duration of ICP in the study group (6.3 ± 2.7 min vs. 4.5 ± 2.1 min, t=3.917) was longer than that of the control group (P<0.01). The difference between CPP (20.4 ± 2.7 mmHg vs. 15.5 ± 1.6 mmHg, t=9.874) and MAP (8.9 ± 2.7 mmHg vs. 6.7 ± 3.8 mmHg, t=2.985) before and after treatment was higher than that of the control group (P<0.01). After treatment, the patiets number of improvement in the study group were 29 cases (72.5%) and the control group 20 cases (72.5%). The improvemewnt rate of the two groups was statistically significant difference (χ2=4.266, P=0.039). Conclusions The combination of Lishui-Huayu decoction combined with mild hypothermia can prolong the duration of ICP low value, reduce ICP and improve patient prognosis. Key words: Craniocerebral trauma; Intracranial hypertension; Lishui-Huayu decoction; Hypothermia, induced