Abstract

Dalam mencapai tujuan utama terapi yaitu mencapai kontrol lokal tumor setinggi mungkin dan efek samping pada jaringan normal seminimal mungkin, diperlukan pemahaman yang mendasar mengenai mekanisme kematian sel, baik sel normal maupun sel ganas. Mekanisme kematian tersebut digambarkan oleh model matematis linear kuadratik. Model linear kuadratik memberikan gambaran mengenai rasio α/β, menjadi landasan kuantitatif dari fraksinasi, dan membantu interpretasi treatment planning.

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