Abstract
Chloramphenicol at a constant concentration inhibited the polymerization of phenylalanine in a bacterial ribosome-polyuridylic acid system by a constant percentage when graded concentrations of ribosomes, polyuridylic acid, or transfer ribonucleic acid limited the activity of the system. [ 14C]Cloramphenicol combined weakly but stereospecifically with 70-S ribosomes; the average number of chloramphenicol molecules binding to a ribosome was of the order of 1. The hypothesis is proposed that ribosome-bound chloramphenicol interferes with a function of messenger ribonucleic acid.
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