Abstract
Abstract Background and Aims Oxidative stress represents a risk factor for cardiovascular complications . The aim of the work is to evaluate the effectiveness of vitamin E on cardiovascular complications in hemodialysis patients. Method a study including 420 patients on hemodialysis and 360 controls. Treatment with Vit E at a rate of 300 mg / day for 2 years. All patients benefited from a blood sample of oxidative stress markers as well as paraclinical explorations in search of cardiovascular complications. Results The study grouped together 780 cases. We find that there is a significant relationship between cardiovascular complications and Advanced Oxidation Protein Product (AOPP), Low Density Oxidized Lipoprotein (LDLox), Malondialdehydes (MDA) and Gluthations), we did not find any correlation with nitrogen monoxide (NO) and myeloperoxidases (MPO) .Concerning gluthations (IU / ml ) we observe that the mean values clearly increased after treatment (P-value <0.05) . The mean value of MDA µmol / l significantly decreased after treatment .we note that the cardiovascular complications have decreased (11.03% versus 16.04%) with the decrease in certain markers of oxidative stress. (p > 0.05) Conclusion Regarding cardiovascular complications, we have certainly noticed a drop in their frequency after treatment with vit E without the difference being significant.
Published Version
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