MO556: Markers of Oxidative Stress and Coronary Calcifications in Chronic Hemodialysis Patients

Abstract

Abstract BACKGROUND AND AIMS Cardiovascular morbidity and mortality are increased in hemodialysis patients. Oxidative stress is considered to be an important factor in these cardiovascular complications in these patients. The aim of this research is to establish the link between the levels of advanced oxidation protein products (AOPP) in the serum of hemodialysis patients and coronary calcifications. METHOD This is a longitudinal study involving 67 hemodialysis patients, all patients underwent a Coro-CT scan to assess coronary calcifications according to the Agatston coronary calcium score (SCCA). We divided the patients into three groups according to their low (0–100), medium (101–400) and severe calcification score > 400, we measured the levels of AOPP in the three groups and we studied the correlation between the rate of AOPP at the level of the different groups. RESULTS The mean age of the patients is 55 ± 12.5 years, the sex ratio is 1.3, the mean us-CRP level is 12.5 mg/L, the mean NO, AOPP, MDA level, MPO and LDLox are respectively (62.188 ± 5.598, 70.82 ± 10, 6.97 ± 0.488 µmol/L, 61.466 ± 8.82 IU/mL and 31.755 ± 3.9 µmol/l), we divided the patients into three groups according to the agtston coronary calcium score (SCCA), we found 27% of the patients had a low score (0–100), 48% had a moderate sore (101–400) and 25% had a severe score >400. We found that the rate of oxidative stress markers worsened with increasing calcification score, patients with a low score had levels of NO, AOPP, MDA, MPO and LDLox are respectively (67.2 ± 6.5, 64.9 ± 7, 3.24 ± 0.32, 57.8 ± 6.9 IU/mL and 10.17 ± 1.9 µmol/l), the mean score had respective levels of NO, AOPP, MDA, MPO and LDLox are respectively (62.5 ± 3.2, 72.7 ± 12, 7.2 ± 0.24 µmol/L, 60.34 ± 5.7 IU/mL and 27.6 ± 2.1 µmol/L) and patients with a severe calcification score had NO, AOPP, MDA, MPO and LDLox levels respectively (59.3 ± 2.4, 82.82 ± 12, 9.45 ± 0.34 µmol/L, 74.23 ± 9.7 IU/mL and 42.89 ± 5.19 µmol/L), there are positive correlations between the rate of coronary calcifications and the levels of markers oxidative stress NO, AOPP, MDA, MPO and LDLox) which are respectively (r = 0744, P = 0.0001; r = 0.777, P = 0.000; r = 0.318, P = 0.000; r = 0.620, P = 0.000; r = 0.526, P = 0.0001). CONCLUSION Markers of oxidative stress are higher in hemodialysis patients with vascular calcifications, they can be predictors of cardiovascular complications in hemodialysis patients.