Mitochondrial Dysfunction and Their Management by Antioxidants

Abstract

For normal cell functioning generation of ATP is very important, and it is produced by mitochondria, and they also an important organelle. When sometimes mitochondrial dysfunction occur produces high energy will be demanded, and it is critical for cells such as signal transmission between neuronal cells and also affects cardiomyocytes. Mitochondria and their role to act as power house of the cell and through reactive oxygen species they transmit signaling between molecule and also determination of cellular fate. But sometimes the reactive oxygen species generated more that time, for maintaining normal homeostatic mitochondrial function rapid activation of antioxidant defense system that is required by mitochondrial electron transport. But that time antioxidant defense system is not responded properly or absent that cause mitochondrial dysfunction is occurred at that time they produce degenerative diseases in human beings that is nervous system, and they significantly contribute to produce a cardiac pathology because mitochondria are more abundant in cardiac tissues due to mitochondrial dysfunction, and also they are involved in lung related diseases that is asbestos, lung cancer, chronic airway disease and lung fibrosis. When compared to nuclear DNA the mitochondrial DNA is more sensitive to oxidants because they encode the mitochondrial proteins. When damages to mitochondrial DNA, that case impairment occurs in electron transport chain and potential loss in mitochondrial membrane. In this review I concluded that by, oxidative stress induced mitochondrial dysfunction produced lung related heart related and neurological related disease and their one of the way of prevention is by antioxidant induced mitochondrial biogenesis.