Abstract
Our understanding of the relevance of the vitamin D metabolism in human skin has significantly improved during the last years. Today it is commonly accepted that vitamin D deficiency is not only associated with affections of the bone- and calcium-metabolism, but also with an elevated risk for multiple other diseases (e. g. different cancers, cardio-vascular-diseases, infections, autoimmune diseases) . The skin is the only organ that is capable of synthesizing vitamin D after exposure to sunlight. On the other hand, UV-exposure is one of the major risk factors for epithelial skin cancer. Thus there is a conflict between positive and negative properties of sunlight. In this article we summarize the current scientific knowledge about the importance of the vitamin D metabolism in the skin. Furthermore, we elucidate new aspects about the use of vitamin D and its analoga in dermatology, especially in the prevention of skin cancer and in the therapy of psoriasis.
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