Microwave assisted synthesis of benzimidazole derivatives using tetra butyl ammonium chloride as phase transfer catalyst, characterization, biological activities and molecular docking studies

Abstract

Benzimidazole and its derivatives are of wide interest because of their diverse biological activity and clinical applications. The heterocyclic imidazole core is a common moiety in a large number of natural products and pharmacologically active compounds and because of that they are possessing inhibitory activity as well as favorable selectivity ratio. Benzimidazoles exhibit significant activities like anti-microbial, anti-viral, anti-diabetic, anti-cancer activity, numerous antioxidants, anti-parasitic, anti-helmintics, antiproliferative, anti-HIV, anti-convulsant, antiinflammatory, anti-hypertensive, anti-neoplastic, proton pump inhibitor and anti-trichinellosis. The synthesis of benzimidazole derivatives remains a focus of medicinal research. Here benzimidazole derivatives were synthesized using two phase system under microwave conditions using the phase transfer catalyst tetra butyl ammonium chloride (10% mol) in good yield. The molecular docking study against 4GQQ protein with synthesized benzimidazole derivatives was performed to see the necessary interactions responsible for anti-bacterial activity.