Microsurgical endonasal transsphenoidal approach for 46 patients with pituitary adenomas

Abstract

Objective To explore the effect of microsurgical endonasal transsphenoidal approach on the treatment of pituitary adenomas.Methods The clinical data of 46 cases with pituitary adenomas treated through microsurgical endonasal transsphenoidal approach were retrospectively analyzed.The relevant endocrine index and MRI were checked during the follow-up and the clinical effect and complication were analyzed.Results 38 cases achieved follow-up.There were 32 (84.2％) cases of total resection and 6 (15.8％) cases of subtotal resection.28 patients (93.3％) had vision improved in 30 patients with decreased vision before operation.24 patients(75.0％) got normal menstruation in 32 patients with menstrual disorder.4 patients (57.1％) got better in 7 patients with acromegaly.12 patients(75.0％) got normal endocrine in 16 hyper-prolactin patients.4 patients(57.1％) got normal growth hormone in 7 patients with somatotrophinomas.There was one postoperative death.12 cases (24.4％) suffered postoperative insipidus in 45 patients.Cerebrospinal rhinorrhea occurred in 3 patients(6.7％,3/45) postoperatively.Postoperative hyperglycemia occurred in 9 cases (20.0％,9/45).Conclusion Microsurgical endonasal transsphenoidal approach provides the first choice for operation of pituitary adenomas,which is effective and safe with reliable effect. Key words: Pituitary neoplasms ; Microsurgery; Sphenoid sinus