Abstract
Novel bioactive glass (BG)/hydroxyapatite (HAP) composites were successfully manufactured by electrostatic spray deposition (ESD) to improve the overall osteointegration of Ti6Al4V-based implants. Herein, we combined the high bioactivity of the S58 formulation with the long-term stability of HAP. Highly porous coral-like S58 BG coatings with different thicknesses (6 and 30 μm) were deposited on the top of a thin (150 nm) and dense nanocrystalline HAP layer starting from homogeneous liquid precursor solutions by ESD. In vitro studies were carried out by immersion in simulated body fluid (SBF) solution and compared with single-layered coatings of S58 and HAP. The SBF test revealed that the presence of the BG-topcoat layer significantly improves the reactivity in terms of mineralization response compared to single-layered HAP coating. Furthermore, the S58 coating thickness was found to influence the biological response. The thinner composite is suggested to have a better mineralization performance than the thicker one.
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